2023
The role of midkine in health and disease
Emely Elisa Neumaier, Veit Rothhammer, Mathias Linnerbauer
Front Immunol . 2023. doi: 10.3389/fimmu.2023.1310094
PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation
Mathias Linnerbauer #, Tobias Beyer #, Lucy Nirschl, Daniel Farrenkopf, Lena Lößlein, Oliver Vandrey, Anne Peter, Thanos Tsaktanis, Hania Kebir, David Laplaud, Rupert Oellinger, Thomas Engleitner, Jorge Ivan Alvarez, Roland Rad, Thomas Korn, Bernhard Hemmer, Francisco J Quintana, Veit Rothhammer
Nature Communications. 2023. doi: 10.1038/s41467-023-40982-8
Impact of Microbiome-Brain Communication on Neuroinflammation and Neurodegeneration
Iris Stolzer, Eveline Scherer, Patrick Süß, Veit Rothhammer, Beate Winner, Markus F Neurath, Claudia Günther
Int J Mol Sci . 2023. doi: 10.3390/ijms241914925
Gut immune cell trafficking: inter-organ communication and immune-mediated inflammation
Sebastian Zundler, Claudia Günther, Andreas E Kremer, Mario M Zaiss, Veit Rothhammer, Markus F Neurath
Nat Rev Gastroenterol Hepatol . 2023. doi: 10.1038/s41575-022-00663-1
Association between cognition and gait in multiple sclerosis: A smartphone-based longitudinal analysis
Alzhraa A Ibrahim, Werner Adler, Heiko Gaßner, Veit Rothhammer, Felix Kluge, Bjoern M Eskofier
Int J Med Inform. 2023. doi: 10.1016/j.ijmedinf.2023.105145
Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells
Liliana M Sanmarco, Joseph M Rone, Carolina M Polonio, Gonzalo Fernandez Lahore, Federico Giovannoni, Kylynne Ferrara, Cristina Gutierrez-Vazquez, Ning Li, Anna Sokolovska, Agustin Plasencia, Camilo Faust Akl, Payal Nanda, Evelin S Heck, Zhaorong Li, Hong-Gyun Lee, Chun-Cheih Chao, Claudia M Rejano-Gordillo, Pedro H Fonseca-Castro, Tomer Illouz, Mathias Linnerbauer, Jessica E Kenison, Rocky M Barilla, Daniel Farrenkopf, Nikolas A Stevens, Gavin Piester, Elizabeth N Chung, Lucas Dailey, Vijay K Kuchroo, David Hava, Michael A Wheeler, Clary Clish, Roni Nowarski, Eduardo Balsa, Jose M Lora, Francisco J Quintana
Nature. 2023. doi: 10.1038/s41586-023-06409-6
Microglial expression of CD83 governs cellular activation and restrains neuroinflammation in experimental autoimmune encephalomyelitis
Pia Sinner, Katrin Peckert-Maier, Hashem Mohammadian, Christine Kuhnt, Christina Draßner, Vasiliki Panagiotakopoulou, Simon Rauber, Mathias Linnerbauer, Zhana Haimon, Dmytro Royzman, Deborah Kronenberg-Versteeg, Andreas Ramming, Alexander Steinkasserer, Andreas B Wild
Nature Communications. 2023. doi: 10.1038/s41467-023-40370-2
Regulation of the programmed cell death protein 1/programmed cell death ligand 1 axis in relapsing-remitting multiple sclerosis
Thanos Tsaktanis #, Mathias Linnerbauer, Lena Lößlein, Daniel Farrenkopf, Oliver Vandrey, Anne Peter, Ana Cirac, Tobias Beyer, Lucy Nirschl, Verena Grummel, Mark Mühlau, Matthias Bussas, Bernhard Hemmer, Francisco J Quintana, Veit Rothhammer
Brain Communications. 2023. doi: 10.1093/braincomms/fcad206
Cerebrospinal fluid biomarkers for cerebral amyloid angiopathy
Jochen A Sembill, Christoph Lusse, Mathias Linnerbauer, Maximilian I Sprügel, Anne Mrochen, Michael Knott, Tobias Engelhorn, Manuel Alexander Schmidt, Arnd Doerfler, Timo Jan Oberstein, Juan Manuel Maler, Johannes Kornhuber, Piotr Lewczuk, Veit Rothhammer, Stefan Schwab, Joji B Kuramatsu
Brain Communications. 2023. doi: 10.1093/braincomms/fcad159
Droplet-based forward genetic screening of astrocyte-microglia cross-talk
Michael A Wheeler #, Iain C Clark #, Hong-Gyun Lee #, Zhaorong Li, Mathias Linnerbauer, Joseph M Rone, Manon Blain, Camilo Faust Akl, Gavin Piester, Federico Giovannoni, Marc Charabati, Joon-Hyuk Lee, Yoon-Chul Kye, Joshua Choi, Liliana M Sanmarco, Lena Srun, Elizabeth N Chung, Lucas E Flausino, Brian M Andersen, Veit Rothhammer, Hiroshi Yano, Tomer Illouz, Stephanie E J Zandee, Carolin Daniel, David Artis, Marco Prinz, Adam R Abate, Vijay K Kuchroo, Jack P Antel, Alexandre Prat, Francisco J Quintana
Science. 2023. doi: 10.1126/science.abq4822
2022
Identification of environmental factors that promote intestinal inflammation
Liliana M. Sanmarco, Chun-Cheih Chao, Yu-Chao Wang, Jessica E. Kenison, Zhaorong Li, Joseph M. Rone, Claudia M. Rejano-Gordillo, Carolina M. Polonio, Cristina Gutierrez-Vazquez, Gavin Piester, Agustin Plasencia, Lucinda Li, Federico Giovannoni, Hong-Gyun Lee, Camilo Faust Akl, Michael A. Wheeler, Ivan Mascanfroni, Merja Jaronen, Moneera Alsuwailm, Patrick Hewson, Ada Yeste, Brian M. Andersen, Diana G. Franks, Chien-Jung Huang, Millicent Ekwudo, Emily C. Tjon, Veit Rothhammer, Maisa Takenaka, Kalil Alves de Lima, Mathias Linnerbauer, Lydia Guo, Ruxandra Covacu, Hugo Queva, Pedro Henrique Fonseca-Castro, Maha Al Bladi, Laura M. Cox, Kevin J. Hodgetts, Mark E. Hahn, Alexander Mildner, Joshua Korzenik, Russ Hauser, Scott B. Snapper & Francisco J. Quintana
Nature. 2022. doi: 10.1038/s41586-022-05308-6
An Optimized Comparative Proteomic Approach as a Tool in Neurodegenerative Disease Research
Rachel A. Kline, Lena Lößlein, Dominic Kurian, Judit Aguilar Martí, Samantha L. Eaton, Felipe A. Court , Thomas H. Gillingwater, and Thomas M. Wishart
Cells. 2022. https://doi.org/10.3390/cells11172653
Gut immune cell trafficking: inter-organ communication and immune-mediated inflammation
Sebastian Zundler, Claudia Günther, Andreas E. Kremer, Mario M. Zaiss, Veit Rothhammer & Markus F. Neurath
Nat Rev Gastroenterol Hepatol. 2022. doi.org/10.1038/s41575-022-00663-1
Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis
Mattias Bronge, Klara Asplund Högelin, Olivia G Thomas, Sabrina Ruhrmann, Claudia Carvalho-Queiroz, Ola B Nilsson, Andreas Kaiser, Manuel Zeitelhofer, Erik Holmgren, Mathias Linnerbauer, …, Tomas Olsson and Hans Grönlund
Sci Adv. 2022. DOI: 10.1126/sciadv.abn1823
Intranasal delivery of a small-molecule ErbB inhibitor promotes recovery from acute and late-stage CNS inflammation
Mathias Linnerbauer, Lena Lößlein, Oliver Vandrey, Thanos Tsaktanis, Alexander Beer, Ulrike J. Naumann, Franziska Panier, Tobias Beyer, Lucy Nirschl, Joji B. Kuramatsu, Jürgen Winkler, Francisco J. Quintana, and Veit Rothhammer
JCI Insight. 2022. 10.1172/jci.insight.154824
Astrocyte-Derived Pleiotrophin Mitigates Late-Stage Autoimmune CNS Inflammation
Mathias Linnerbauer, Lena Lößlein, Daniel Farrenkopf, Oliver Vandrey, Thanos Tsaktanis, Ulrike Naumann and Veit Rothhammer
Frontiers in Immunology. 2022. https://doi.org/10.3389/fimmu.2021.800128
2021
The Aryl Hydrocarbon Receptor–Dependent TGF-α/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis
Ana Cirac, Thanos Tsaktanis, Tobias Beyer, Mathias Linnerbauer, Till Andlauer, Verena Grummel, Lucy Nirschl, Lena Loesslein, Francisco J. Quintana, Bernhard Hemmer, Veit Rothhammer
Neurology Neuroimmunology & Neuroinflammation 2021. DOI: https://doi.org/10.1212/NXI.0000000000001043
Barcoded viral tracing of single-cell interactions in central nervous system inflammation
Iain C. Clark*, Cristina Gutiérrez-Vázquez*, Michael A. Wheeler*, Zhaorong Li, Veit Rothhammer, Mathias Linnerbauer, Liliana M. Sanmarco, Lydia Guo, Manon Blain, Stephanie E. J. Zandee, Chun-Cheih Chao, Katelyn V. Batterman, Marius Schwabenland, Peter Lotfy, Amalia Tejeda-Velarde, Patrick Hewson, Carolina Manganeli Polonio, Michael W. Shultis, Yasmin Salem, Emily C. Tjon, Pedro H. Fonseca-Castro, Davis M. Borucki, Kalil Alves de Lima, Agustin Plasencia, Adam R. Abate9, Douglas L. Rosene, Kevin J. Hodgetts, Marco Prinz, Jack P. Antel, Alexandre Prat, Francisco J. Quintana
Science 2021. DOI: 10.1126/science.abf1230
Accumulation of cytotoxic T cells in the aged CNS leads to axon degeneration and contributes to cognitive and motor decline
Janos Groh, Konrad Knöpper, Panagiota Arampatzi, Xidi Yuan, Lena Lößlein, Antoine-Emmanuel Saliba, Wolfgang Kastenmüller & Rudolf Martini
Nat Aging 2021. https://doi.org/10.1038/s43587-021-00049-z
Aryl Hydrocarbon Receptor Activation in Astrocytes by Laquinimod Ameliorates Autoimmune Inflammation in the CNS
Veit Rothhammer, Jessica E Kenison, Zahorong Li, Emily Tjon, Maisa C Takenaka, Chun-Cheih Chao, Kalil Alves de Lima, Davis M Borucki, Joel Kaye, Francisco J Quintana
Neurol Neuroimmunol Neuroinflamm 2021. DOI: 10.1212/NXI.0000000000000946
A cell-based drug delivery platform for treating central nervous system inflammation
Oren Levy*, Veit Rothhammer*, Ivan Mascanfroni, Zhixiang Tong, Rui Kuai, Michael De Biasio, Qingping Wang, Tahir Majid, Christelle Perrault, Ada Yeste, Jessica E. Kenison, Helia Safaee, Juliet Musabeyezu, Martina Heinelt, Yuka Milton, Heidi Kuang, Haoyue Lan, William Siders, Marie-Christine Multon, Jonathan Rothblatt, Salam Massadeh, Manal Alaamery, Ali H. Alhasan, Francisco J. Quintana & Jeffrey M. Karp
Journal of Molecular Medicine 2021. https://doi.org/10.1007/s00109-020-02003-9
Gut-licensed IFNy+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
Liliana M. Sanmarco*, Michael A. Wheeler*, Cristina Gutiérrez-Vázquez, Carolina Manganeli Polonio, Mathias Linnerbauer, Felipe A. Pinho-Ribeiro, Zhaorong Li, Federico Giovannoni, Katelyn V. Batterman, Giulia Scalisi, Stephanie E. J. Zandee, Evelyn S. Heck, Moneera Alsuwailm, Douglas L. Rosene, Burkhard Becher, Isaac M. Chiu, Alexandre Prat & Francisco J. Quintana
Nature 2021. https://www.nature.com/articles/s41586-020-03116-4
2020
Aryl Hydrocarbon Receptor Plasma Agonist Activity Correlates With Disease Activity in Progressive MS
Thanos Tsaktanis, Tobias Beyer, Lucy Nirschl, Mathias Linnerbauer, Verena Grummel, Mathias Bussas, Emily Tjon, Mark Mühlau, Thomas Korn, Bernhard Hemmer, Francisco J. Quintana, Veit Rothhammer
Neurology Neuroimmunology & Neuroinflammation 2020. https://doi.org/10.1212/NXI.0000000000000933
Protective functions of reactive astrocytes following central nervous system insult
Mathias Linnerbauer, Veit Rothhammer
Front. Immunol. 2020. doi: 10.3389/fimmu.2020.573256
Astrocyte Crosstalk in CNS Inflammation
Mathias Linnerbauer, Michael Wheeler, Francisco J. Quintana
Neuron, 2020. https://doi.org/10.1016/j.neuron.2020.08.012
AHR is a Zika virus host factor and a candidate target for antiviral therapy
Federico Giovannoni, Irene Bosch, Carolina Manganeli Polonio, María F Torti, Michael A Wheeler, Zhaorong Li, Leonardo Romorini, María S Rodriguez Varela, Veit Rothhammer, Andreia Barroso, Emily C Tjon, Liliana M Sanmarco, Maisa C Takenaka, Seyed Mohamad Sadegh Modaresi, Cristina Gutiérrez-Vázquez, Nágela Ghabdan Zanluqui, Nilton Barreto Dos Santos, Carolina Demarchi Munhoz, Zhongyan Wang, Elsa B Damonte, David Sherr, Lee Gehrke, Jean Pierre Schatzmann Peron, Cybele C Garcia, Francisco J Quintana.
Nat Neurosci. 2020;23(8):939-951. doi:10.1038/s41593-020-0664-0
2019
The Aryl Hydrocarbon Receptor: An Environmental Sensor Integrating Immune Responses in Health and Disease
Rothhammer V, Quintana FJ.
Nat Rev Immunol. 2019;19(3):184‐197. doi:10.1038/s41577-019-0125-8
Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS
Chao CC, Gutiérrez-Vázquez C, Rothhammer V, et al.
Cell. 2019;179(7):1483‐1498.e22. doi:10.1016/j.cell.2019.11.016
IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis
Lindahl H, Guerreiro-Cacais AO, Bedri SK, Linnerbauer M, et al.
J Immunol. 2019;203(4):888‐898. doi:10.4049/jimmunol.1900400
2018
Microglial control of astrocytes in response to microbial metabolites
Rothammer, V., Borucki, D.M., Tjon, E.C. et al.
Nature 557, 724–728 (2018). doi:10.1038/s41586-018-0119-x
Detection of Aryl Hydrocarbon Receptor Agonists in Human Samples
Rothhammer V, Borucki DM, Kenison JE, et al.
Sci Rep. 2018;8(1):4970. Published 2018 Mar 21. doi:10.1038/s41598-018-23323-4
2017
Sphingosine 1-phosphate Receptor Modulation Suppresses Pathogenic Astrocyte Activation and Chronic Progressive CNS Inflammation
Rothhammer V, Kenison JE, Tjon E, et al.
Proc Natl Acad Sci U S A. 2017;114(8):2012‐2017. doi:10.1073/pnas.1615413114
Dynamic Regulation of Serum Aryl Hydrocarbon Receptor Agonists in MS
Rothhammer V, Borucki DM, Garcia Sanchez MI, et al.
Neurol Neuroimmunol Neuroinflamm. 2017;4(4):e359. Published 2017 Jun 16. doi:10.1212/NXI.0000000000000359
2016
Type I Interferons and Microbial Metabolites of Tryptophan Modulate Astrocyte Activity and Central Nervous System Inflammation via the Aryl Hydrocarbon Receptor
Rothhammer V, Mascanfroni ID, Bunse L, et al.
Nat Med. 2016;22(6):586‐597. doi:10.1038/nm.4106
Environmental Control of Autoimmune Inflammation in the Central Nervous System
Rothhammer V, Quintana FJ.
Curr Opin Immunol. 2016;43:46‐53. doi:10.1016/j.coi.2016.09.002
2015
Control of Autoimmune CNS Inflammation by Astrocytes
Rothhammer V, Quintana FJ.
Semin Immunopathol. 2015;37(6):625‐638. doi:10.1007/s00281-015-0515-3
Cleavage and Cell Adhesion Properties of Human Epithelial Cell Adhesion Molecule (HEPCAM)
Tsaktanis T, Kremling H, Pavšič M, et al.
J Biol Chem. 2015;290(40):24574‐24591. doi:10.1074/jbc.M115.662700