2025
TGFa controls checkpoints in CNS resident and infiltrating immune cells to promote resolution of inflammation
Lena Lößlein, Mathias Linnerbauer, Finnja Zuber, Thanos Tsaktanis, Oliver Vandrey, Anne Peter, Franziska Panier, Julia Zissler, Vivienne Riekher, Tobias Bäuerle, Jannis Hanspach, Frederik B. Laun, Lisa Nagel, Lisa Mészáros, Friederike Zunke, Jürgen Winkler, Ulrike J. Naumann, Nora Schwingen, Emely Neumaier, Arthur Liesz, Francisco Quintana, Veit Rothhammer
Nature Communications. 2025. doi: 10.1038/s41467-025-60363-7
Worse recovery from acute attacks and faster disability accumulation highlights the unmet need for improved treatment in patients with late-onset neuromyelitis optica spectrum disorders (COPTER-LO study)
Julian Reza Kretschmer, Daria Tkachenko, Tania Kümpfel, Joachim Havla, Daniel Engels, Friedemann Paul, Patrick Schindler, Judith Bellmann-Strobl, Achim Berthele, Katrin Giglhuber, Clarissa Zappe, Luisa Klotz, Lisa Revie, Eva Dawin, Makbule Senel, Hayrettin Tumani, Florian Then Bergh, Clemens Warnke, Markus Kraemer, Annette Walter, Antonios Bayas, Uwe K Zettl, Ann-Sophie Lauenstein, Yavor Yalachkov, Thorleif Etgen, Matthias Kaste, Felix Luessi, Stefan Gingele, Sarah Passoke, Martin S Weber, Jörn Peter Sieb, Axel Haarmann, Patrick Oschmann, Veit Rothhammer, Christian Geis, Markus C Kowarik, Peter Kern, Matthias Grothe, Heike Stephanik, Klemens Angstwurm, Frank Hoffmann, Ulrike Wallwitz, Brigitte Wildemann, Sven Jarius, Jan-Patrick Stellmann, Thivya Pakeerathan, Carolin Schwake, Ilya Ayzenberg, Ingo Kleiter, Katinka Fischer, Orhan Aktas, Marius Ringelstein, Vivien Häußler, Corinna Trebst, Martin W Hümmert
Front. Immunol. 2025. doi: 10.3389/fimmu.2025.1575613
Cognitive-motor interference in multiple sclerosis revisited: a dual-task paradigm using wearable inertial sensors and the Paced Auditory Serial Addition Test
Lea Kremer, Lucas Schreff, Daniel Hamacher, Patrick Oschmann, Veit Rothhammer, Philipp M Keune, Roy Müller
Front Neurol. 2025. doi: 10.3389/fneur.2025.1546183
CLEC16A in astrocytes promotes mitophagy and limits pathology in a multiple sclerosis mouse model
Atsushi Kadowaki, Michael A Wheeler, Zhaorong Li, Brian M Andersen, Hong-Gyun Lee, Tomer Illouz, Joon-Hyuk Lee, Alain Ndayisaba, Stephanie E J Zandee, Himanish Basu, Chun-Cheih Chao, Joao V Mahler, Wendy Klement, Dylan Neel, Matthew Bergstresser, Veit Rothhammer, Gabriel Lipof, Lena Srun, Scott A Soleimanpour, Isaac Chiu, Alexandre Prat, Vikram Khurana, Francisco J Quintana
Nat Neurosci. 2025. doi: 10.1038/s41593-025-01875-9
Modulator of VRAC Current 1 Is a Potential Target Antigen in Multiple Sclerosis
Johannes Raffael Dahl, Alicia Weier, Christopher Winter, Maik Hintze, Veit Rothhammer, Thanos Tsaktanis, Anne-Katrin Proebstel, Tradite Neziraj, Elisabeth Poessnecker, Johanna Oechtering, Jens Kuhle, Boris-Alexander Kallmann, Gabriele Luber, Thorsten Heider, Luisa Klotz, Rittika Chunder, Stefanie Kuerten
Neurol Neuroimmunol Neuroinflamm. 2025. doi: 10.1212/NXI.0000000000200374
Real-world multicentre cohort study on choices and effectiveness of immunotherapies in NMOSD and MOGAD
Vivien Häußler, Corinna Trebst, Daniel Engels, Hanna Pellkofer, Joachim Havla, Ankelien Duchow, Patrick Schindler, Carolin Schwake, Thivya Pakeerathan, Katinka Fischer, Marius Ringelstein, Gero Lindenblatt, Martin W Hümmert, Daria Tkachenko, Franziska Bütow, Katrin Giglhuber, Martina Flaskamp, Insa Schiffmann, Mirjam Korporal-Kuhnke, Sven Jarius, Eva Dawin, Lisa Revie, Makbule Senel, Mariella Herfurth, Annette Walter, Mosche Pompsch, Ingo Kleiter, Klemens Angstwurm, Matthias Kaste, Matthias Grothe, Jonathan Wickel, Paulus Stefan Rommer, Jörn Peter Sieb, Markus Krämer, Florian Then Bergh, Hayrettin Tumani, Luisa Klotz, Brigitte Wildemann, Orhan Aktas, Ilya Ayzenberg, Judith Bellmann-Strobl, Friedemann Paul, Tania Kümpfel, Tim Friede, Achim Berthele, Jan-Patrick Stellmann; Neuromyelitis optica study group (NEMOS)
J Neurol Neurosurg Psychiatry. 2025. doi: 10.1136/jnnp-2024-334764
2024
Case report: Cerebrospinal fluid neutrophilic pleocytosis upon intrathecal triamcinolone injection
Thanos Tsaktanis, Jenny Stritzelberger, Vi Tuong Daniel To, Martin Uhl, Stefan Schwab, Dieter Heuss, Veit Rothhammer
Front Neurol. 2024. doi: 10.3389/fneur.2024.1372266
Expression of Inflammatory Mediators in Biofilm Samples and Clinical Association in Multiple Sclerosis Patients in Remission-A Pilot Study
Jakob Fehlhofer, Jutta Ries, Florian Tobias Nickel, Veit Rothhammer, Stefan Schwab, Marco Kesting, Mayte Buchbender
Life (Basel). 2024. doi: 10.3390/life14030367
Gut-Brain Interactions and Their Impact on Astrocytes in the Context of Multiple Sclerosis and Beyond
Julia Zissler, Veit Rothhammer, Mathias Linnerbauer
Cells. 2024. doi: 10.3390/cells13060497
Disease-associated astrocyte epigenetic memory promotes CNS pathology
Hong-Gyun Lee, Joseph M. Rone, Zhaorong Li, Camilo Faust Akl, Seung Won Shin, Joon-Hyuk Lee, Lucas E. Flausino, Florian Pernin, Chun-Cheih Chao, Kilian L. Kleemann, Lena Srun, Tomer Illouz, Federico Giovannoni, Marc Charabati, Liliana M. Sanmarco, Jessica E. Kenison, Gavin Piester, Stephanie E. J. Zandee, Jack P. Antel, Veit Rothhammer, Michael A. Wheeler, Alexandre Prat, Iain C. Clark & Francisco J. Quintana
Nature. 2024. doi: 10.1038/s41586-024-07187-5
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology
Mathias Linnerbauer, Lena Lößlein, Oliver Vandrey, Anne Peter, Yanan Han, Thanos Tsaktanis, Emile Wogram, Maria Needhamsen, Lara Kular, Lisa Nagel, Julia Zissler, Marie Andert, Lisa Meszaros, Jannis Hanspach, Finnja Zuber, Ulrike J. Naumann, Martin Diebold, Michael A. Wheeler, Tobias Beyer, Lucy Nirschl, Ana Cirac, Frederik B. Laun, Claudia Günther, Jürgen Winkler, … Veit Rothhammer
Nature Immunology. 2024. doi: 10.1038/s41590-024-01756-6
Author Correction: Disease-associated astrocyte epigenetic memory promotes CNS pathology
Hong-Gyun Lee, Joseph M Rone, Zhaorong Li, Camilo Faust Akl, Seung Won Shin, Joon-Hyuk Lee, Lucas E Flausino, Florian Pernin, Chun-Cheih Chao, Kilian L Kleemann, Lena Srun, Tomer Illouz, Federico Giovannoni, Marc Charabati, Liliana M Sanmarco, Jessica E Kenison, Gavin Piester, Stephanie E J Zandee, Jack P Antel , Veit Rothhammer, Michael A Wheeler, Alexandre Prat, Iain C Clark, Francisco J Quintana
Nature. 2024. doi: 10.1038/s41586-024-07734-0
Meningitis and intracranial abscess due to Mycoplasma pneumoniae in a B cell-depleted patient with multiple sclerosis
Dominik Madžar, Florian T Nickel, Veit Rothhammer, Philipp Goelitz, Walter Geißdörfer, Roger Dumke, Roland Lang
Eur J Clin Microbiol Infect Dis. 2024. doi: 10.1007/s10096-024-04935-3
Correction: Fehlhofer et al. Expression of Inflammatory Mediators in Biofilm Samples and Clinical Association in Multiple Sclerosis Patients in Remission-A Pilot Study.
Jakob Fehlhofer, Jutta Ries, Florian Tobias Nickel, Veit Rothhammer, Stefan Schwab, Marco Kesting, Mayte Buchbender
Life (Basel). 2024. doi: 10.3390/life14080932
Eculizumab Use in Neuromyelitis Optica Spectrum Disorders: Routine Clinical Care Data From a European Cohort
Marius Ringelstein, Susanna Asseyer, Gero Lindenblatt, Katinka Fischer, Refik Pul, Jelena Skuljec, Lisa Revie, Katrin Giglhuber, Vivien Häußler, Michael Karenfort, Kerstin Hellwig, Friedemann Paul, Judith Bellmann-Strobl, Carolin Otto, Klemens Ruprecht, Tjalf Ziemssen, Alexander Emmer, Veit Rothhammer, Florian T Nickel, Klemens Angstwurm, Ralf Linker, Sarah A Laurent, Clemens Warnke, Sven Jarius, Mirjam Korporal-Kuhnke, Brigitte Wildemann, Stephanie Wolff, Maria Seipelt, Yavor Yalachkov, Nele Retzlaff, Uwe K Zettl, Paulus S Rommer, Markus C Kowarik, Jonathan Wickel, Christian Geis, Martin W Hümmert, Corinna Trebst, Makbule Senel, Ralf Gold, Luisa Klotz, Christoph Kleinschnitz, Sven G Meuth, Orhan Aktas, Achim Berthele, Ilya Ayzenberg; German Neuromyelitis Optica Study Group (NEMOS)
Neurology. 2025. doi: 10.1212/WNL.0000000000209888
Cognition in patients with myelin oligodendrocyte glycoprotein antibody-associated disease: a prospective, longitudinal, multicentre study of 113 patients (CogniMOG-Study)
Sarah Passoke, Carlotta Stern, Vivien Häußler, Tania Kümpfel, Joachim Havla, Daniel Engels, Sven Jarius, Brigitte Wildemann, Mirjam Korporal-Kuhnke, Makbule Senel, Jan-Patrick Stellmann, Clemens Warnke, Matthias Grothe, Rasmus Schülke, Stefan Gingele, Julian Reza Kretschmer, Luisa Klotz, Annette Walter, Florian Then Bergh, Orhan Aktas, Marius Ringelstein, Ilya Ayzenberg, Carolin Schwake, Ingo Kleiter, Pia Sophie Sperber, Rebekka Rust, Patrick Schindle, Judith Bellmann-Strobl, Friedemann Paul, Bruno Kopp, Corinna Trebst, Martin W Hümmert, Neuromyelitis Optica Study Group (NEMOS)
J Neurol Neurosurg Psychiatry. 2024. doi: 10.1136/jnnp-2024-333994
Neuroinflammatory disease signatures in SPG11-related hereditary spastic paraplegia patients
Laura Krumm, Tatyana Pozner, Naime Zagha, Roland Coras, Philipp Arnold, Thanos Tsaktanis, Kathryn Scherpelz, Marie Y. Davis, Johanna Kaindl, Iris Stolzer, Patrick Süß, Mukhran Khundadze, Christian A. Hübner, Markus J. Riemenschneider, Jonathan Baets, Claudia Günther, Suman Jayadev, Veit Rothhammer, Florian Krach, Jürgen Winkler, Beate Winner & Martin Regensburger
Acta Neuropathol. 2024. doi: 10.1007/s00401-023-02675-w
Disease-associated astrocyte epigenetic memory promotes CNS pathology
Hong-Gyun Lee, Joseph M Rone, Zhaorong Li, Camilo Faust Akl, Seung Won Shin, Joon-Hyuk Lee, Lucas E Flausino, Florian Pernin, Chun-Cheih Chao, Kilian L Kleemann, Lena Srun, Tomer Illouz, Federico Giovannoni, Marc Charabati, Liliana M Sanmarco, Jessica E Kenison, Gavin Piester, Stephanie E J Zandee, Jack Antel, Veit Rothhammer, Michael A Wheeler, Alexandre Prat, Iain C Clark, Francisco J Quintana
2024. doi: 10.1101/2024.01.04.574196
2023
The role of midkine in health and disease
Emely Elisa Neumaier, Veit Rothhammer, Mathias Linnerbauer
Front Immunol . 2023. doi: 10.3389/fimmu.2023.1310094
PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation
Mathias Linnerbauer Tobias Beyer, Lucy Nirschl, Daniel Farrenkopf, Lena Lößlein, Oliver Vandrey, Anne Peter, Thanos Tsaktanis, Hania Kebir, David Laplaud, Rupert Oellinger, Thomas Engleitner, Jorge Ivan Alvarez, Roland Rad, Thomas Korn, Bernhard Hemmer, Francisco J Quintana, Veit Rothhammer
Nature Communications. 2023. doi: 10.1038/s41467-023-40982-8
Impact of Microbiome-Brain Communication on Neuroinflammation and Neurodegeneration
Iris Stolzer, Eveline Scherer, Patrick Süß, Veit Rothhammer, Beate Winner, Markus F Neurath, Claudia Günther
Int J Mol Sci . 2023. doi: 10.3390/ijms241914925
Gut immune cell trafficking: inter-organ communication and immune-mediated inflammation
Sebastian Zundler, Claudia Günther, Andreas E Kremer, Mario M Zaiss, Veit Rothhammer, Markus F Neurath
Nat Rev Gastroenterol Hepatol . 2023. doi: 10.1038/s41575-022-00663-1
The Role of Gut and Oral Microbiota in the Formation and Rupture of Intracranial Aneurysms: A Literature Review
Ann-Kathrin Joerger, Carolin Albrecht, Veit Rothhammer, Klaus Neuhaus, Arthur Wagner, Bernhard Meyer, Maria Wostrack
Int J Mol Sci. 2023. 10.3390/ijms25010048
Association between cognition and gait in multiple sclerosis: A smartphone-based longitudinal analysis
Alzhraa A Ibrahim, Werner Adler, Heiko Gaßner, Veit Rothhammer, Felix Kluge, Bjoern M Eskofier
Int J Med Inform. 2023. doi: 10.1016/j.ijmedinf.2023.105145
Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells
Liliana M Sanmarco, Joseph M Rone, Carolina M Polonio, Gonzalo Fernandez Lahore, Federico Giovannoni, Kylynne Ferrara, Cristina Gutierrez-Vazquez, Ning Li, Anna Sokolovska, Agustin Plasencia, Camilo Faust Akl, Payal Nanda, Evelin S Heck, Zhaorong Li, Hong-Gyun Lee, Chun-Cheih Chao, Claudia M Rejano-Gordillo, Pedro H Fonseca-Castro, Tomer Illouz, Mathias Linnerbauer, Jessica E Kenison, Rocky M Barilla, Daniel Farrenkopf, Nikolas A Stevens, Gavin Piester, Elizabeth N Chung, Lucas Dailey, Vijay K Kuchroo, David Hava, Michael A Wheeler, Clary Clish, Roni Nowarski, Eduardo Balsa, Jose M Lora, Francisco J Quintana
Nature. 2023. doi: 10.1038/s41586-023-06409-6
Microglial expression of CD83 governs cellular activation and restrains neuroinflammation in experimental autoimmune encephalomyelitis
Pia Sinner, Katrin Peckert-Maier, Hashem Mohammadian, Christine Kuhnt, Christina Draßner, Vasiliki Panagiotakopoulou, Simon Rauber, Mathias Linnerbauer, Zhana Haimon, Dmytro Royzman, Deborah Kronenberg-Versteeg, Andreas Ramming, Alexander Steinkasserer, Andreas B Wild
Nature Communications. 2023. doi: 10.1038/s41467-023-40370-2
Regulation of the programmed cell death protein 1/programmed cell death ligand 1 axis in relapsing-remitting multiple sclerosis
Thanos Tsaktanis #, Mathias Linnerbauer, Lena Lößlein, Daniel Farrenkopf, Oliver Vandrey, Anne Peter, Ana Cirac, Tobias Beyer, Lucy Nirschl, Verena Grummel, Mark Mühlau, Matthias Bussas, Bernhard Hemmer, Francisco J Quintana, Veit Rothhammer
Brain Communications. 2023. doi: 10.1093/braincomms/fcad206
Cerebrospinal fluid biomarkers for cerebral amyloid angiopathy
Jochen A Sembill, Christoph Lusse, Mathias Linnerbauer, Maximilian I Sprügel, Anne Mrochen, Michael Knott, Tobias Engelhorn, Manuel Alexander Schmidt, Arnd Doerfler, Timo Jan Oberstein, Juan Manuel Maler, Johannes Kornhuber, Piotr Lewczuk, Veit Rothhammer, Stefan Schwab, Joji B Kuramatsu
Brain Communications. 2023. doi: 10.1093/braincomms/fcad159
Droplet-based forward genetic screening of astrocyte-microglia cross-talk
Michael A Wheeler #, Iain C Clark #, Hong-Gyun Lee #, Zhaorong Li, Mathias Linnerbauer, Joseph M Rone, Manon Blain, Camilo Faust Akl, Gavin Piester, Federico Giovannoni, Marc Charabati, Joon-Hyuk Lee, Yoon-Chul Kye, Joshua Choi, Liliana M Sanmarco, Lena Srun, Elizabeth N Chung, Lucas E Flausino, Brian M Andersen, Veit Rothhammer, Hiroshi Yano, Tomer Illouz, Stephanie E J Zandee, Carolin Daniel, David Artis, Marco Prinz, Adam R Abate, Vijay K Kuchroo, Jack P Antel, Alexandre Prat, Francisco J Quintana
Science. 2023. doi: 10.1126/science.abq4822
2022
Identification of environmental factors that promote intestinal inflammation
Liliana M. Sanmarco, Chun-Cheih Chao, Yu-Chao Wang, Jessica E. Kenison, Zhaorong Li, Joseph M. Rone, Claudia M. Rejano-Gordillo, Carolina M. Polonio, Cristina Gutierrez-Vazquez, Gavin Piester, Agustin Plasencia, Lucinda Li, Federico Giovannoni, Hong-Gyun Lee, Camilo Faust Akl, Michael A. Wheeler, Ivan Mascanfroni, Merja Jaronen, Moneera Alsuwailm, Patrick Hewson, Ada Yeste, Brian M. Andersen, Diana G. Franks, Chien-Jung Huang, Millicent Ekwudo, Emily C. Tjon, Veit Rothhammer, Maisa Takenaka, Kalil Alves de Lima, Mathias Linnerbauer, Lydia Guo, Ruxandra Covacu, Hugo Queva, Pedro Henrique Fonseca-Castro, Maha Al Bladi, Laura M. Cox, Kevin J. Hodgetts, Mark E. Hahn, Alexander Mildner, Joshua Korzenik, Russ Hauser, Scott B. Snapper & Francisco J. Quintana
Nature. 2022. doi: 10.1038/s41586-022-05308-6
An Optimized Comparative Proteomic Approach as a Tool in Neurodegenerative Disease Research
Rachel A. Kline, Lena Lößlein, Dominic Kurian, Judit Aguilar Martí, Samantha L. Eaton, Felipe A. Court , Thomas H. Gillingwater, and Thomas M. Wishart
Cells. 2022. https://doi.org/10.3390/cells11172653
Gut immune cell trafficking: inter-organ communication and immune-mediated inflammation
Sebastian Zundler, Claudia Günther, Andreas E. Kremer, Mario M. Zaiss, Veit Rothhammer & Markus F. Neurath
Nat Rev Gastroenterol Hepatol. 2022. doi.org/10.1038/s41575-022-00663-1
Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis
Mattias Bronge, Klara Asplund Högelin, Olivia G Thomas, Sabrina Ruhrmann, Claudia Carvalho-Queiroz, Ola B Nilsson, Andreas Kaiser, Manuel Zeitelhofer, Erik Holmgren, Mathias Linnerbauer, …, Tomas Olsson and Hans Grönlund
Sci Adv. 2022. DOI: 10.1126/sciadv.abn1823
Intranasal delivery of a small-molecule ErbB inhibitor promotes recovery from acute and late-stage CNS inflammation
Mathias Linnerbauer, Lena Lößlein, Oliver Vandrey, Thanos Tsaktanis, Alexander Beer, Ulrike J. Naumann, Franziska Panier, Tobias Beyer, Lucy Nirschl, Joji B. Kuramatsu, Jürgen Winkler, Francisco J. Quintana, and Veit Rothhammer
JCI Insight. 2022. 10.1172/jci.insight.154824
Astrocyte-Derived Pleiotrophin Mitigates Late-Stage Autoimmune CNS Inflammation
Mathias Linnerbauer, Lena Lößlein, Daniel Farrenkopf, Oliver Vandrey, Thanos Tsaktanis, Ulrike Naumann and Veit Rothhammer
Frontiers in Immunology. 2022. https://doi.org/10.3389/fimmu.2021.800128
2021
The Aryl Hydrocarbon Receptor–Dependent TGF-α/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis
Ana Cirac, Thanos Tsaktanis, Tobias Beyer, Mathias Linnerbauer, Till Andlauer, Verena Grummel, Lucy Nirschl, Lena Loesslein, Francisco J. Quintana, Bernhard Hemmer, Veit Rothhammer
Neurology Neuroimmunology & Neuroinflammation 2021. DOI: https://doi.org/10.1212/NXI.0000000000001043
Barcoded viral tracing of single-cell interactions in central nervous system inflammation
Iain C. Clark*, Cristina Gutiérrez-Vázquez*, Michael A. Wheeler*, Zhaorong Li, Veit Rothhammer, Mathias Linnerbauer, Liliana M. Sanmarco, Lydia Guo, Manon Blain, Stephanie E. J. Zandee, Chun-Cheih Chao, Katelyn V. Batterman, Marius Schwabenland, Peter Lotfy, Amalia Tejeda-Velarde, Patrick Hewson, Carolina Manganeli Polonio, Michael W. Shultis, Yasmin Salem, Emily C. Tjon, Pedro H. Fonseca-Castro, Davis M. Borucki, Kalil Alves de Lima, Agustin Plasencia, Adam R. Abate9, Douglas L. Rosene, Kevin J. Hodgetts, Marco Prinz, Jack P. Antel, Alexandre Prat, Francisco J. Quintana
Science 2021. DOI: 10.1126/science.abf1230
Accumulation of cytotoxic T cells in the aged CNS leads to axon degeneration and contributes to cognitive and motor decline
Janos Groh, Konrad Knöpper, Panagiota Arampatzi, Xidi Yuan, Lena Lößlein, Antoine-Emmanuel Saliba, Wolfgang Kastenmüller & Rudolf Martini
Nat Aging 2021. https://doi.org/10.1038/s43587-021-00049-z
Aryl Hydrocarbon Receptor Activation in Astrocytes by Laquinimod Ameliorates Autoimmune Inflammation in the CNS
Veit Rothhammer, Jessica E Kenison, Zahorong Li, Emily Tjon, Maisa C Takenaka, Chun-Cheih Chao, Kalil Alves de Lima, Davis M Borucki, Joel Kaye, Francisco J Quintana
Neurol Neuroimmunol Neuroinflamm 2021. DOI: 10.1212/NXI.0000000000000946
A cell-based drug delivery platform for treating central nervous system inflammation
Oren Levy*, Veit Rothhammer*, Ivan Mascanfroni, Zhixiang Tong, Rui Kuai, Michael De Biasio, Qingping Wang, Tahir Majid, Christelle Perrault, Ada Yeste, Jessica E. Kenison, Helia Safaee, Juliet Musabeyezu, Martina Heinelt, Yuka Milton, Heidi Kuang, Haoyue Lan, William Siders, Marie-Christine Multon, Jonathan Rothblatt, Salam Massadeh, Manal Alaamery, Ali H. Alhasan, Francisco J. Quintana & Jeffrey M. Karp
Journal of Molecular Medicine 2021. https://doi.org/10.1007/s00109-020-02003-9
Gut-licensed IFNy+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
Liliana M. Sanmarco*, Michael A. Wheeler*, Cristina Gutiérrez-Vázquez, Carolina Manganeli Polonio, Mathias Linnerbauer, Felipe A. Pinho-Ribeiro, Zhaorong Li, Federico Giovannoni, Katelyn V. Batterman, Giulia Scalisi, Stephanie E. J. Zandee, Evelyn S. Heck, Moneera Alsuwailm, Douglas L. Rosene, Burkhard Becher, Isaac M. Chiu, Alexandre Prat & Francisco J. Quintana
Nature 2021. https://www.nature.com/articles/s41586-020-03116-4
2020
Aryl Hydrocarbon Receptor Plasma Agonist Activity Correlates With Disease Activity in Progressive MS
Thanos Tsaktanis, Tobias Beyer, Lucy Nirschl, Mathias Linnerbauer, Verena Grummel, Mathias Bussas, Emily Tjon, Mark Mühlau, Thomas Korn, Bernhard Hemmer, Francisco J. Quintana, Veit Rothhammer
Neurology Neuroimmunology & Neuroinflammation 2020. https://doi.org/10.1212/NXI.0000000000000933
Protective functions of reactive astrocytes following central nervous system insult
Mathias Linnerbauer, Veit Rothhammer
Front. Immunol. 2020. doi: 10.3389/fimmu.2020.573256
Astrocyte Crosstalk in CNS Inflammation
Mathias Linnerbauer, Michael Wheeler, Francisco J. Quintana
Neuron, 2020. https://doi.org/10.1016/j.neuron.2020.08.012
AHR is a Zika virus host factor and a candidate target for antiviral therapy
Federico Giovannoni, Irene Bosch, Carolina Manganeli Polonio, María F Torti, Michael A Wheeler, Zhaorong Li, Leonardo Romorini, María S Rodriguez Varela, Veit Rothhammer, Andreia Barroso, Emily C Tjon, Liliana M Sanmarco, Maisa C Takenaka, Seyed Mohamad Sadegh Modaresi, Cristina Gutiérrez-Vázquez, Nágela Ghabdan Zanluqui, Nilton Barreto Dos Santos, Carolina Demarchi Munhoz, Zhongyan Wang, Elsa B Damonte, David Sherr, Lee Gehrke, Jean Pierre Schatzmann Peron, Cybele C Garcia, Francisco J Quintana.
Nat Neurosci. 2020;23(8):939-951. doi:10.1038/s41593-020-0664-0
2019
The Aryl Hydrocarbon Receptor: An Environmental Sensor Integrating Immune Responses in Health and Disease
Rothhammer V, Quintana FJ.
Nat Rev Immunol. 2019;19(3):184‐197. doi:10.1038/s41577-019-0125-8
Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS
Chao CC, Gutiérrez-Vázquez C, Rothhammer V, et al.
Cell. 2019;179(7):1483‐1498.e22. doi:10.1016/j.cell.2019.11.016
IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis
Lindahl H, Guerreiro-Cacais AO, Bedri SK, Linnerbauer M, et al.
J Immunol. 2019;203(4):888‐898. doi:10.4049/jimmunol.1900400
2018
Microglial control of astrocytes in response to microbial metabolites
Rothammer, V., Borucki, D.M., Tjon, E.C. et al.
Nature 557, 724–728 (2018). doi:10.1038/s41586-018-0119-x
Detection of Aryl Hydrocarbon Receptor Agonists in Human Samples
Rothhammer V, Borucki DM, Kenison JE, et al.
Sci Rep. 2018;8(1):4970. Published 2018 Mar 21. doi:10.1038/s41598-018-23323-4
2017
Sphingosine 1-phosphate Receptor Modulation Suppresses Pathogenic Astrocyte Activation and Chronic Progressive CNS Inflammation
Rothhammer V, Kenison JE, Tjon E, et al.
Proc Natl Acad Sci U S A. 2017;114(8):2012‐2017. doi:10.1073/pnas.1615413114
Dynamic Regulation of Serum Aryl Hydrocarbon Receptor Agonists in MS
Rothhammer V, Borucki DM, Garcia Sanchez MI, et al.
Neurol Neuroimmunol Neuroinflamm. 2017;4(4):e359. Published 2017 Jun 16. doi:10.1212/NXI.0000000000000359
2016
Type I Interferons and Microbial Metabolites of Tryptophan Modulate Astrocyte Activity and Central Nervous System Inflammation via the Aryl Hydrocarbon Receptor
Rothhammer V, Mascanfroni ID, Bunse L, et al.
Nat Med. 2016;22(6):586‐597. doi:10.1038/nm.4106
Environmental Control of Autoimmune Inflammation in the Central Nervous System
Rothhammer V, Quintana FJ.
Curr Opin Immunol. 2016;43:46‐53. doi:10.1016/j.coi.2016.09.002
2015
Control of Autoimmune CNS Inflammation by Astrocytes
Rothhammer V, Quintana FJ.
Semin Immunopathol. 2015;37(6):625‐638. doi:10.1007/s00281-015-0515-3
Cleavage and Cell Adhesion Properties of Human Epithelial Cell Adhesion Molecule (HEPCAM)
Tsaktanis T, Kremling H, Pavšič M, et al.
J Biol Chem. 2015;290(40):24574‐24591. doi:10.1074/jbc.M115.662700